Monogenic Diabetes with GATA6 Mutations: Characterization of a Novel Family and a Comprehensive Analysis of the GATA6 Clinical and Genetics Traits.

Monogenic diabetes caused by GATA6 mutations were almost described as neonatal diabetes, and the phenotypic spectrum has expanded since then. Our study underscores the broad phenotypic spectrum by reporting a de novo GATA6 mutation in a family. Furthermore, we reviewed related literature to summarize the clinical and genetic characteristics of monogenic diabetes with GATA6 mutations (n = 39) in order to improve clinicians' understanding of the disease. We conclude that the GATA6 missense mutation (c. 749G > T, p. Gly250Val) is not reported presently, characterized by adult-onset diabetes with pancreatic dysplasia and located in transcriptional activation region. Carries with GATA6 mutations (n = 55) have a variable spectrum of diabetes, ranging from neonatal (72.7%), childhood-onset (20%) to adults-onset (7.5%). 83.5% of patients with abnormal pancreatic development. Heart and hepatobillary defects are the most common abnormalities of extrapancreatic features. Most mutations with GATA6 are loss of function (LOF, 71.8%) and located in functional region. Functional studies mostly support loss-of-function as the pathophysiological mechanism. In conclusion, there are various types of diabetes with GATA6 mutations, which can also occur in adult diabetes. Phenotypic defects with GATA6 mutations are most frequently malformations of pancreas and heart. This highlights the importance of comprehensive clinical evaluation of identified carriers to evaluate their full phenotypic spectrum.

[Optical properties of one-dimensional metallodielectric photonic crystals].

The optical characteristics of one-dimensional metallodielectric photonic crystals (MDPC), constructed by inserting metal aluminum layers of certain thickness into the Si/SiO2 system, were studied theoretically with the transfer matrix method. The results show that the reflection efficiency can be enhanced considerably after the introduction of metallic layers, e. g. the rejection level of each period increased from 7.2 dB([Si(46 nm)/SiO2 (120 nm)]5) to 20 dB ([Si(46 nm)/SiO2 (60 nm)/Al (10 nm)/SiO2 (60 nm)]5). In addition, high omnidirectional reflection band with broader width can be obtained, e. g. bandwidth of 550 nm can be offered with [Si(46 nm)/SiO2 (60 nm)/Al (30 nm)/SiO2 (60 nm)]5. Rules of how the absorption, thickness and position of the metal layers affect the optical characteristics of the MDPC are also discussed. These MDPC structures may be used as compact-size, low-loss and broad-band optical reflectors.